I think the OP is asking which position is the better "off"?
If I understand correctly - they are wanting to know is it better to have the blocking "T" portion with flow or against flow. In a simple 2 way valve - I prefer to have it positioned so the flow pushes the "T" portion into the side of the housing - so in that case - the handle end points towards the pump. In a suction arrangement - I prefer to have the "T" portion positioned so the suction pulls the "T" portion into the side housing - thus the handle end points away from the pump.
For simplicity:
For a 2 way - I think of it as an arrow, not a "T", the arrow would point in the direction of flow to stop flow.
For a 3 way - which I consider a diverter valve, I would think you never want to totally stop flow, so then I would have the handle end point towards the pump/supply.
-Tom